- Nevada offered the GOP a chance to flip a seat, with former state Attorney General Adam Laxalt leading in most polls against incumbent Democrat Catherine Cortez Masto.
- In the end, Laxalt failed to oust Cortez Masto.
- Another key Senate race included Ohio, where Republican J.D. Vance defeated longtime Democratic Rep. Tim Ryan to help the GOP hold the seat vacated by retiring Sen. Rob Portman.